Meta-analysis of clinical efficacy of soft silicone dressing for treating radiation-induced skin reaction

doi:10.3969/j.issn.2095-4344.1741

Abstract

Abstract:

BACKGROUND: Soft silicone dressing has been reported to improve the skin situation for patients suffering from radiotherapy, but these studies are small-sample trials. Therefore, it is necessary to evaluate the studies at home and abroad addressing that soft silicone dressing applied in the patients undergoing radiotherapy by meta-analysis.

OBJECTIVE: To investigate the differences in the effectiveness of soft silicone dressing and conventional nursing in the prevention and treatment of radiation-induced skin reaction.

METHODS: Databases of CNKI, CBM, WanFang, PubMed, and Cochrane Library were searched to retrieve the randomized clinical trials or non-randomized clinical trials concerning the effects of soft silicone dressing and conventional nursing in radiation-induced skin reaction. Meta-analysis was conducted using RevMan 5.3 software.

RESULTS AND CONCLUSION: Eleven studies were enrolled, involving 1 284 patients. The patients received the soft silicone dressing (trial group) and conventional nursing (control group) to treat and prevent radiation-induced skin reaction. Meta-analysis revealed that compared with the control group, in the trial group, there was an decrease the incidence of moist desquamation [OR=0.13, 95%CI (0.09, 0.19, P < 0.05], grade II, III and IV [OR=0.30, 95%CI (0.21, 0.44), P < 0.05; OR=0.14, 95%CI (0.07, 0.28), P < 0.05; OR=0.06, 95%CI (0.01, 0.47), P < 0.05], combined RISRAS score was decreased [OR=-1.12, 95%CI (-2.21, -0.04, P < 0,05], pain degree was alleviated [MD=-1.44, 95%CI (-1.93, -0.95), P < 0.05], incidence of painless was increased [OR=4.83, 95%CI (2.93, 7.99), P < 0.05], and the wound healing time was shortened [OR=-6.03, 95%CI (-7.47, -4.59, P < 0.05]. These results indicate that soft silicone dressing can relieve the severity of radiation-induced skin reaction and pain, and accelerate wound healing compared with the conventional nursing, which is a rational and effective method in the prevention and treatment of radiation-induced skin reaction.

Key words: soft silicone dressing, radiation-induced skin reaction, radiodermatitis, conventional nursing, moist desquamation, RIOG, RISRAS, pain, healing time, meta-analysis

CLC Number:

Shi Xueping, Lei Youjin, Zeng Zhumei, Luo Jianghe, Huang Ruina, Yang Ming. Meta-analysis of clinical efficacy of soft silicone dressing for treating radiation-induced skin reaction[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(22): 3591-3598.

Figures/Tables 9

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